AUTHOR LOGIN Close
Please enter author credentials to view Author Manual
Username:
Password:  
   
for New Author Registration
JAYPEE JOURNALS
International Scientific Journals from Jaypee
IndexCopernicus Value: 91.57
Home Instructions Editorial Board Current Issue Pubmed Archives Subscription Advertisement Contact Us
 
LOGIN  
Username: Password:
 
New Author Registration | Forgot Password ?
 
 
 
Most Downloaded Articles of the Journal
 
 
List of All Articles
1.  Research Article
A Case-Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria)
Hichem Abdessalem MAÏ, Abbassia Demmouche
[Year:2015] [Month:September-December] [Volume:6 ] [Number:3] [Pages:43] [Pages No:103-107] [No of Hits : 1641]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1110 | FREE

ABSTRACT

Introduction: The prevalence of obesity and female infertility in Algeria has increased in past decades, and recent study are showing a relationship between body mass index (BMI) and the risk of female infertility, suggesting that obesity is a risk factor for infertility. In order to evaluate the risk of infertility associated with BMI, we conducted a case-control study.

Materials and methods: The relationship between BMI and female infertility was investigated in a case-control study of 256 infertile cases and 326 fertile control subjects. The BMI of infertile women was compared with the BMI of the control fertile group. Odds ratios (ORs) was calculated as measures of relative risk of infertility associated with BMI.

Results: Multiple analyses showed significant association between various measures of BMI and female infertility in this population. An association between BMI and infertility was observed for the overweight (25.00-29.99 kg/m2; odds ratio = 2.23; p = 0.021; 95% confidence interval, 1.52-3.25) and obese group (> 30 kg/m2; odds ratio = 3.26; p = 0.019; 95% confidence interval, 1.62-6.58) compared to the normal weight group. However, no association was found between underweight and infertility (BMI < 20 Kg/m2, odds ratio = 0.96; p = 0.063; 95% confidence interval, 0.57-1.63).

Conclusion: The present study confirms the results that the previously reported research have shown and affirm that an negative association exist between obesity and overweight with fertility, this association might be influenced by other factors, that’s why larger and more research in the Algerian population are needed.

Keywords: Algeria, Body mass index, Female infertility, Obesity, Overweight.

How to cite this article: MAÏ HA, Demmouche A. A Case- Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria). Int J Infertil Fetal Med 2015;6(3):103-107.

Source of support: Nil

Conflict of interest: None

 
2.  Review Article
Granulocyte Colony Stimulating Factor for Treatment of Thin Endometrium in Assisted Reproduction Technology Cycles
Mohan S Kamath, Prasad Lele
[Year:2015] [Month:September-December] [Volume:6 ] [Number:3] [Pages:43] [Pages No:97-102] [No of Hits : 1145]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1109 | FREE

ABSTRACT

Granulocyte colony stimulating factor (G-CSF), a glycoprotein, belongs to colony stimulating factor family and mainly regulates the growth and differentiation of granulocytes. However, it also plays an important role in endometrial stromal cell decidualization, ovulation, implantation, placental metabolism, trophoblast development and endometrial regeneration. It is due to these effects, it has been used in difficult clinical scenarios, such as unresponsive thin endometrium during assisted reproductive technology treatment, repeated implantation failure and recurrent miscarriages. Most of the studies have investigated its use in thin endometrium. In this review, we have summarized the current updated evidence with regards to use of G-CSF in women with thin endometrium.

Keywords: Assisted reproductive technology, Granulocyte colony stimulating factor, Thin endometrium.

How to cite this article: Kamath MS, Lele P. Granulocyte Colony Stimulating Factor for Treatment of Thin Endometrium in Assisted Reproduction Technology Cycles. Int J Infertil Fetal Med 2015;6(3):97-102.

Source of support: Nil

Conflict of interest: None

 
3.  Research Article
Novel Design of an Intrauterine Insemination Cannula
Ritvik Vasan
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:15-19] [No of Hits : 770]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1095 | FREE

ABSTRACT

Intrauterine insemination (IUI) is a method of assisted conception that involves transfer of fast moving sperms using an IUI cannula into the uterine cavity at the time of anticipated (or expected) ovulation, thereby increasing chance of pregnancy.
Existing cannulas are designed to be easy to use, harmless to the cervix/endometrium, capable of negotiating the cervical cavity, and to avoid the reflux of inseminate fluid. Some of the factors which influence success of pregnancy are actual number of motile sperms, number of sperms with normal morphology, volume of inseminate and sterility during procedure. This paper proposes a novel ‘completely closed loop’ design for an IUI cannula that ensures complete emptying of washed sperm during insemination, leaving no dead space while ensuring sterility during procedure.

Keywords: Intrauterine insemination, Cannula, Insemination, Catheter, Stillet.

How to cite this article: Vasan R. Novel Design of an Intrauterine Insemination Cannula. Int J Infertil Fetal Med 2015;6(1): 15-19.

Source of Support: This work was supported by Manipal Ankur, Bengaluru, India.

Conflict of Interest: None

Date of Received: 08-01-15

Date of Acceptance: 10-02-15

Date of Publication: April 2015

 
4.  Editorial
Editorial
Kamini A Rao
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:vii] [No of Hits : 705]
Full Text PDF | Abstract | FREE

ABSTRACT

Dear Readers,
Greetings and good wishes!!
Gonadotropin-releasing hormone (GnRH) antagonists can be used to prevent luteinizing hormone surge during controlled ovarian stimulation without hypoestrogenic side effects, flare up, or long downregulation period associated with agonists. It acts through competitive binding to pituitary GnRH receptors, which allows their use at any time during the follicular phase. It is well-proven that it is associated with lower incidence of ovarian hyperstimulation syndrome and it has got comparable clinical outcomes with agonist protocols. To throw more light on this matter, we have a review article by Dr. Divya Sardana on antagonists.

 
5.  Original Article
Identification of Fetal Growth Patterns with Customized Growth Charts: A prospective study in South India
Badanahatti Radhika, Vavilala Suseela, Praveen Kumar Nirmalan
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:30-34] [No of Hits : 614]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1098 | FREE

ABSTRACT

Aim: To determine the diagnostic effectiveness of symphysis fundus height (SFH) measures plotted on customized growth charts for the identification of fetal growth patterns in a tertiary care perinatal center in south India.

Materials and methods: Serial SFH of pregnant women with singleton babies booked for antenatal care up to 22 weeks was measured from 24 weeks of gestation and plotted on customized growth charts that were developed using the gestation related optimal weight (GROW) software downloaded from www.gestation.net to identify fetal growth patterns. Fetal growth patterns were also ascertainedusing ultrasound in the antenatal period and confirmed at birth using a neonatal growth classification. The diagnostic effectiveness of SFH was compared with ultrasound and neonatal classifications using sensitivity, specificity, area under the ROC curve and likelihood ratio tests.

Results: The study included 666 pregnant women who presented at the antenatal clinics from January 2010 to October 2010. On ultrasound examination, 564 (84.6%) fetuses were AGA, 78 (11.7%) fetuses were LGA and 19 (2.9%) were SGA and 5 (0.8%) showed crossing centile from higher to lower pattern. On serial SFH measures, 426 (64.0%) of the fetuses were normal growth, 180 (27.0%) were excessive growth and 40 (6.0%) were slow growth. Serial SFH measures had a positive likelihood ratio of 4.7 (8.5 for USG) for the identification of SGA and a negative likelihood ratio of 0.06 for the detection of LGA.

Conclusion: The SFH measures plotted on a customized GROW curve have the potential to develop into a low cost screening tool to identify fetuses with altered growth. The diagnostic effectiveness of SFH plotted on customized growth charts has to be improved further through the development of appropriate customized growth charts for India before application on a larger scale.

Keywords: Fetal growth, Growth curves, SGA, LGA, Customization, Grow.

How to cite this article: Radhika B, Suseela V, Nirmalan PK. Identification of Fetal Growth Patterns with Customized Growth Charts: A prospective study in South India. Int J Infertil Fetal Med 2015;6(1):30-34.

Source of Support: The study was supported by the Fernandez Hospital Educational and Research Foundation, Hyderabad.

Conflict of Interest: None

Date of Received: 22-01-15

Date of Acceptance: 15-03-15

Date of Publication: April 2015

 
6.  REVIEW ARTICLE
Role of Anti-Müllerian Hormone in Gynecology: A Review of Literature
Naina Kumar, Amit Kant Singh
[Year:2015] [Month:May-August] [Volume:6 ] [Number:2] [Pages:52] [Pages No:51-61] [No of Hits : 610]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1102 | FREE

ABSTRACT

Anti-müllerian hormone (AMH) or Müllerian inhibiting substance (MIS), is a dimeric protein part of the transforming growth factor (TGF)-beta subfamily. It plays two important roles in follicle genesis. First, it delays entrance of primordial follicle into pool of follicles in growth and secondly, it decreases the sensitivity of ovarian follicle toward follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing non-selected follicles makes AMH an ideal marker for size of the ovarian follicle pool. This review summarizes recent literature concerning AMH and its role in various gynecological conditions.

Methods: The literature regarding AMH was searched from various English language journals and published peer-reviewed articles on Pubmed, MEDLINE and Google Scholar till 2014.

Keywords: Antral follicle, Infertility, Ovarian reserve.

How to cite this article: Kumar N, Singh AK. Role of Antimüllerian Hormone in Gynecology: A Review of Literature. Int J Infertil Fetal Med 2015;6(2):51-61.

Source of support: Nil

Conflict of interest: None

Date of received: 15-05-15

Date of acceptance: 25-07-15

Date of publication: August 2015

 
7.  Review Article
Review on Antagonists
Divya Sardana
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:1-10] [No of Hits : 554]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1093 | FREE

ABSTRACT

Gonadotropin-releasing hormone (GnRH) antagonists have been a breakthrough in reproductive medicine. The third generation antagonists (cetrorelix and ganirelix) do not have histamine releasing capability in the used doses. The competitive blockade of GnRH receptors by GnRH antagonists leads to an immediate but reversible arrest of gonadotropin secretion. Antagonists can be used as single-dose or multiple dose protocol in a fixed or flexible approach during ovarian stimulation to prevent premature luteinizing hormone surge. The stimulation remains close to the normal cycle, and more convenient and friendly to the patient with lesser dose and duration of stimulation. Recent Cochrane analysis suggests that there is no significant difference in the live birth rate when antagonists are compared with agonists (OR 0.86) and there is a significant reduction in the incidence of ovarian hyperstimulation syndrome (OHSS) (OR 0.43) with the use of antagonists. Gonadotropin-releasing hormone antagonists are of special benefit for use in patients with polycystic ovaries where agonist trigger can be used and OHSS can be prevented completely. Gonadotropin-releasing hormone antagonists have particular advantage in poor responders with lesser pituitary suppression in the early part of cycle. Gonadotropinreleasing hormone antagonists can be used in modified natural cycle, intrauterine insemination cycles, and frozen embryo transfer cycles. Novel uses of antagonists include suppression of established OHSS, and in various gynecological conditions (endometriosis, fibroids, precocious puberty).

Keywords: Antagonist, In vitro fertilization, OHSS, Poor responder.

How to cite this article: Sardana D. Review on Antagonists. Int J Infertil Fetal Med 2015;6(1):1-10.

Source of Support: Nil

Conflict of Interest: None

Date of Received: 11-01-15

Date of Acceptance: 15-02-15

Date of Publication: April 2015

 
8.  Research Article
Combined Tamoxifen and L-Carnitine Therapies for the Treatment of Idiopathic Male Infertility Attending Intracytoplasmic Sperm Injection: A Randomized Controlled Trial
Milat Haje, Kameel Naoom
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:20-24] [No of Hits : 550]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1096 | FREE

ABSTRACT

Aim: The aim of the present study is to evaluate the fertility outcomes of intracytoplasmic sperm injection (ICSI) as well as sperm count, motility and morphology in couples with infertile male partners exhibiting idiopathic oligoasthenozoospermia (OA) and treated with tamoxifen citrate and/or L-carnitine.

Materials and methods: In this randomized controlled trail, couples with female cause of infertility were excluded. Only couples with male cause of infertility with idiopathic OA were admitted to this study and randomly assigned into four different groups of treatments as follow: Group A (n = 45) received an anti-estrogen compound (tamoxifen 20 mg/day), group B (n = 20) received L-carnitine (1000 mg/day), group C (n = 34) received tamoxifen 20 mg/day plus L-carnitine 1000 mg/day, whereas group D (n = 29) received placebo. Treatments were continued for 3 to 6 months.

Results: Treatment groups of A, B, and C showed an overall improvement in the tested parameters of sperm when compared to the control group that showed an overall reduction in those parameters after termination of the treatment. In this context, sperm count increased from 7.58 ± 2.93 × 106/ml before treatment to 10.81 ± 1.84 × 106/ml after treatment in group A (p = 0.016). Similarly, sperm count increased from 5.32 ± 2.09 × 106/ml to 8.92 ± 2.29 × 106/ml in group C (p = 0.01). Patients from group C did not only have an improved total motility of sperm from 8.03 ± 1.59% to 13.78 ± 3.85% (p = 0.045) but also an improved sperm normal morphology from 0.88 ± 0.45% to 1.99 ± 0.71% (p = 0.026). Patients from group A or C exhibited an improved ICSI outcomes when compared to those in patients from group B or D (48.9 or 48.3 vs 16.6 or 20, respectively, p = 0.46).

Conclusion: It is concluded that administration of tamoxifen and L-carnitine can improve both sperm parameters of fertility and ICSI outcomes. Combined tamoxifen and L-carnitine treatments result in maximum therapeutic effect in men with idiopathic OA.

Keywords: Tamoxifen, L-Carnitine, Male infertility, ICSI .

How to cite this article: Haje M, Naoom K. Combined Tamoxifen and L-Carnitine Therapies for the Treatment of Idiopathic Male Infertility Attending Intracytoplasmic Sperm Injection: A Randomized Controlled Trial. Int J Infertil Fetal Med 2015;6(1):20-24.

Source of Support: Nil.

Conflict of Interest: None

Date of Received: 10-01-15

Date of Acceptance: 25-03-15

Date of Publication: April 2015

 
9.  ORIGINAL ARTICLE
Effect of Tuberculosis on Ovarian Reserve of Patients undergoing in vitro Fertilization
Prabhjot Singh Hans, Mohan Lal Swarankar, Swati Garg, Manisha Chowdhary, Karnika Tiwari
[Year:2015] [Month:May-August] [Volume:6 ] [Number:2] [Pages:52] [Pages No:73-83] [No of Hits : 550]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1105 | FREE

ABSTRACT

Aim: To assess ovarian reserve, in infertile women with genital tuberculosis, planning to undergo in vitro fertilization (IVF) and to compare it with infertile women without genital tuberculosis, planning to undergo IVF.

Materials and methods: The study group consisted of 100 women with genital tuberculosis and the control group of 100 women who had no present or past history of tuberculosis. A diagnosis of genital tuberculosis was made based either on the results of tests performed from an endometrial aspiration sample or on histopathologic, hysterosalpingography, hysteroscopy, or laparoscopy findings. Basal ovarian reserve studies included measuring serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and E2 on day 3 of a natural cycle. On the same day, the participants underwent a transvaginal ultrasound examination by means of a two-dimensional 5.0 MHz probe fitted to a Toshiba Famio 5. Ovarian volume and number of antral follicles were estimated for each ovary on the same day of hormonal assessment. Control participants underwent the same tests on day 2 or 3 of their menstrual cycle. Unpaired or independent t-test and Chi-square test were used for statistical analysis.

Results: The present study highlights that women with genital tuberculosis have poor ovarian reserve in comparison to women of similar age without tuberculosis.

Conclusion: It can be concluded that there is no single absolute method of assessing ovarian reserve, but a combination of methods can closely predict the outcome of IVF cycles in women with genital tuberculosis.

Keywords: Genital tuberculosis, in vitro fertilization, Ovarian reserve.

How to cite this article: Hans PS, Swarankar ML, Garg S, Chowdhary M, Tiwari K. Effect of Tuberculosis on Ovarian Reserve of Patients undergoing IVF. Int J Infertil Fetal Med 2015;6(2):73-83.

Source of support: Nil

Conflict of interest: None

Date of received: 19-07-15

Date of acceptance: 25-07-15

Date of publication: August 2015

 
10.  REVIEW ARTICLE
New Insights into Infertility Associated with Polycystic Ovarian Syndrome
Praveena Joglekar Pai, Parama Sahoo, Pratap Kumar
[Year:2015] [Month:May-August] [Volume:6 ] [Number:2] [Pages:52] [Pages No:43-50] [No of Hits : 545]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1101 | FREE

ABSTRACT

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder which was thought to be reasonably well understood. However, new diagnostic criteria have evolved over the years just as has the management of associated infertility. Our review looks at the various diagnostic criteria for PCOS and what has prompted the need for a constant change in these. We also analyze the need for various investigations and what new evidence is out there for optimal treatment for infertility associated with this condition.

Keywords: diagnosis, hyperandrogenism, infertility, polycystic ovarian morphology, Polycystic ovarian syndrome.

How to cite this article: Pai PJ, Sahoo P, Kumar P. New Insights into Infertility Associated with Polycystic Ovarian Syndrome. Int J Infertil Fetal Med 2015;6(2):43-50.

Source of support: Nil

Conflict of interest: None

Date of received: 11-06-15

Date of acceptance: 28-07-15

Date of publication: August 2015

 
   Previous |  Next  
Logo
 
     
 
© Jaypee Brothers Medical Publishers (P) Ltd.
logo